5-fluorouracil-caffeic acid cocrystal delivery agent with long-term and synergistic high-performance antitumor effects

Autor:	Yue-Ming Yu, Fan-Zhi Bu, Yu Yu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li
Rok vydání:	2022
Předmět:	Biomedical Engineering Medicine (miscellaneous) General Materials Science Bioengineering Development
Zdroj:	Nanomedicine. 17:2215-2229
ISSN:	1748-6963 1743-5889
Popis:	Aim: To explore how to transform cocrystals of the anticancer drug 5-fluorouracil (FL) with caffeic acid (CF; FL-CF-2H2O) into a nanoformulation, a self-assembly strategy of cocrystal-loaded micelles is proposed. Methods: Nanomicelles were assembled to deliver cocrystal FL-CF-2H2O with synergistic activity, and their in vitro/ vivo properties were evaluated by combining theoretical and experimental methods. Result: More cocrystal was packed into the polymers due to the stronger interaction energy during micellar assembly, producing excellent cytotoxicity and pharmacokinetic behavior, especially synergistic abilities and long-term therapy. Conclusion: This case exemplifies the particular benefits of the self-assembly strategy of cocrystal-loaded micelles in keeping a delicate balance between long-term effects and high efficiency for FL, and offers a feasible technical scheme for cocrystal delivery agents for antitumor drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8f0321ab83c8a4b7ae62b7479a0c8702 https://doi.org/10.2217/nnm-2022-0208 Zobrazit plný text záznamu