5-fluorouracil-caffeic acid cocrystal delivery agent with long-term and synergistic high-performance antitumor effects
Autor: | Yue-Ming Yu, Fan-Zhi Bu, Yu Yu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Nanomedicine. 17:2215-2229 |
ISSN: | 1748-6963 1743-5889 |
Popis: | Aim: To explore how to transform cocrystals of the anticancer drug 5-fluorouracil (FL) with caffeic acid (CF; FL-CF-2H2O) into a nanoformulation, a self-assembly strategy of cocrystal-loaded micelles is proposed. Methods: Nanomicelles were assembled to deliver cocrystal FL-CF-2H2O with synergistic activity, and their in vitro/ vivo properties were evaluated by combining theoretical and experimental methods. Result: More cocrystal was packed into the polymers due to the stronger interaction energy during micellar assembly, producing excellent cytotoxicity and pharmacokinetic behavior, especially synergistic abilities and long-term therapy. Conclusion: This case exemplifies the particular benefits of the self-assembly strategy of cocrystal-loaded micelles in keeping a delicate balance between long-term effects and high efficiency for FL, and offers a feasible technical scheme for cocrystal delivery agents for antitumor drugs. |
Databáze: | OpenAIRE |
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