The prognostic value of abnormally expressed lncRNAs in prostatic carcinoma
| Autor: | Bai-Song Li, Xian-Lan Wu, Ji-Wang Zhang, Shu-Sheng Peng, Yong-Qiang Yuan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty business.industry Hazard ratio General Medicine Publication bias Cochrane Library medicine.disease Confidence interval 03 medical and health sciences Prostate cancer 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Meta-analysis Internal medicine medicine Carcinoma business Survival analysis |
| Zdroj: | Medicine. 96:e9279 |
| ISSN: | 0025-7974 |
| Popis: | BACKGROUND Several long noncoding RNAs (lncRNAs) are abnormally expressed in prostate cancer (PCa), suggesting that they could serve as novel prognostic markers. The current meta-analysis was undertaken to better define the prognostic value of various lncRNAs in PCa. METHODS The PubMed, Embase, Medline, and Cochrane Library databases were systematically searched up to February 19, 2017, to retrieve eligible articles. Outcomes analyzed were biochemical recurrence-free survival (BRFS), overall survival (OS), metastasis-free survival (MFS), and prostate cancer-specific survival (PCSS). Pooled hazard ratios (HRs) and 95% confidence intervals (95%CIs) were calculated using fixed-effects or random-effects models. RESULTS A total of 10 studies, evaluating 11 PCa-related lncRNAs, were included in the meta-analysis. Pooled results indicate that the abnormal expression of candidate lncRNAs in PCa samples predicted poor BRFS (HR: 1.67, 95%CI: 1.37-2.04, P |
| Databáze: | OpenAIRE |
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