| Autor: |
C.J. Lucas, Anna Rezee, J.M.D. Galama, José Ubels-Postma |
| Rok vydání: |
1978 |
| Předmět: |
|
| Zdroj: |
Cellular Immunology. 37:448-458 |
| ISSN: |
0008-8749 |
| DOI: |
10.1016/0008-8749(78)90212-5 |
| Popis: |
In a previous paper it was reported that an inhibitory effect of measles virus on lymphocyte transformation is only observed if replication of measles virus can take place. We subsequently investigated whether virus-induced interferon could be held responsible for the suppressed lymphocyte transformation. This led to the conclusion that virus-induced extracellular interferon is probably not responsible for the observed suppression, since uv-irradiated or ultracentrifuged supernatants of infected lymphocytes did not inhibit. Furthermore, inhibition of the mixed lymphocyte reaction (MLR) occurred even in the presence of noninfected monocytes. This makes it unlikely that monocytes are responsible for mediating the virus-induced immunosuppression. In this study we also investigated whether a lymphocyte function, which does not require cell multiplication, is inhibited by measles virus. The stimulating capacity of lymphocytes infected with measles virus in the MLR was found to be significantly diminished under conditions that exclude infection of the responding cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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