Long-term dietary antioxidant supplementation reduces production of selected inflammatory mediators by murine macrophages

Autor: Guohua Cao, Ruth D. Lipman, D.E. Smith, Alison A. Beharka, Sung Nim Han, Mohsen Meydani, Simin Nikbin Meydani, Dayong Wu, Oskar Adolfsson
Rok vydání: 2000
Předmět:
Zdroj: Nutrition Research. 20:281-296
ISSN: 0271-5317
DOI: 10.1016/s0271-5317(99)00160-8
Popis: Although macrophage (Mo)-derived compounds, including proinflammatory cytokines, prostaglandins (PG), and nitric oxide (NO), play important roles in host defense, excessive or inappropriate production of them has been implicated in the pathogenesis of a variety of inflammatory diseases. Aging is also associated with increased production of Mo compounds involved in inflammation. Short term dietary supplementation with selected antioxidants, such as glutathione (GSH) and vitamin E (E), has been shown to reduce age-related changes in Mo production of inflammatory compounds, but information is limited regarding the effects of long-term supplementation. Nor is information available on other less studied compounds with antioxidant properties, such as melatonin, strawberry extract, or combinations of compounds such as E + GSH. Therefore, we sought to determine if long term, from middle to old age, dietary supplementation of C57BL/6NCrlBR mice with E, GSH, E + GSH, melatonin or strawberry extract could modify age related changes in Mo production of pro- and anti-inflammatory compounds. Eighteen-month-old C57BL/6NCrlBR mice were fed one of the following six semi-synthetic diets for 6 months: 1) control (30 ppm vitamin E), 2) vitamin E supplemented (control + 470 ppm vitamin E), 3) glutathione (GSH) supplemented (control + 0.5% glutathione), 4) vitamin E and glutathione supplemented (control + 470 ppm vitamin E + 0.5% glutathione), 5) melatonin supplemented (control + 11 ppm melatonin), or 6) strawberry extract supplemented (control + 1% strawberry extract). Supplementation with vitamin E or melatonin, but not GSH, E + GSH, or strawberry extract, reduced (p
Databáze: OpenAIRE
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