A Broad Review of Plant-Derived Bioactive Peptides to combat Pathogenic Outbreaks - A Future Peptide based Therapeutic Approach
| Autor: | S. Poojasri, A.K. Ramya, P. Annathai |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Research Journal of Biotechnology. 17:153-161 |
| ISSN: | 2278-4535 0973-6263 |
| DOI: | 10.25303/1709rjbt1530161 |
| Popis: | Cyclotides are plant-derived proteins belonging to globular micro proteins (≈ 25 to 30 amino residues long) class with a cyclized head-to-tail backbone and its structure stabilized by the presence of cystine knot by three disulfide bonds. Cyclotides withstand biochemical degradation and are heat resistant compared to other types of peptides. In addition, conserved amino acids in the region of the cystine knot showed strong tolerance towards genetic errors. Interestingly, their topology makes them suitable for oral administration and cellular membrane transportation via crossing cell membranes. Cyclotides have been strongly potent candidates for designing anti-viral plant-derived peptides to combat newly emerged and reemerged outbreaks and also making them natural scaffold for drug development template. From the recent reports, cyclotides have been genetically engineered to study protein-peptide interactions for targeted drug delivery methods. In this study, we are undertaking a review on the discovery, history, role of cyclotides in Plant's defense mechanism and tools to the characterization of cyclotides, membrane binding efficiency of cyclotides, antiviral property and cyclotide scaffold designing. |
| Databáze: | OpenAIRE |
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