In vitro and in vivo studies of99mTc IgG: A comparison between three labeling methods
| Autor: | J.L. Crudo, M. Viaggi, S. G. de Castiglia |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Globulin
biology Chemistry Health Toxicology and Mutagenesis Immunoglobulin IgG Public Health Environmental and Occupational Health Pollution Molecular biology In vitro Analytical Chemistry Nuclear Energy and Engineering Biochemistry In vivo Polyclonal antibodies Labelling biology.protein Radiology Nuclear Medicine and imaging Chelation Antibody Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 241:173-177 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/bf02347306 |
| Popis: | Polyclonal immunoglobulin IgG was labeled using three different methods: a direct method via 2-mercaptoethanol, an indirect one, in which a chelating group was covalently attached to the protein and the99mTc added as a glucoheptonate complex and a photoactivation method. The properties of99mTc polyclonal antibody labeled by three different methods were assessed by in vitro and in vivo studies. The ratio between inflamed thigh to normal thigh was similar and independent of the method of labeling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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