ChemInform Abstract: Chemo- and Stereoselective Reduction of β-Keto-α-oximino Nitriles by Using Baker′s Yeast

Autor:	Soon Bang Kang, Gyochang Keum, Yong Sup Lee, Jae Wook Lee, Youseung Kim, Kilwoong Mo
Rok vydání:	2015
Předmět:	Reduction (complexity) NMR spectra database Chemistry Lower yield Stereoselectivity General Medicine Enantiomer Enantiomeric excess Medicinal chemistry Yeast
Zdroj:	ChemInform. 46
ISSN:	0931-7597
DOI:	10.1002/chin.201524042
Popis:	The baker’s yeast mediated reduction of β-keto-α-oximino nitriles 3 at 20 °C gave β-hydroxy-α-oximino nitriles 4 in high yields with high enantiomeric purity [enantiomeric excess (ee) values 99%]. At room temperature, the same reaction afforded the product in a slightly lower yield. The β-hydroxyα-oximino nitriles 4 were obtained as single stereoisomers according to chiral GC–MS analyses and the 1 H and 19 F NMR spectra of the corresponding Mosher esters. The abso
Databáze:	OpenAIRE
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