A case of lung adenocarcinoma complicated by pulmonary talcosis occurring in a patient employed in the confectionery industry

Autor: Tatsuhiko Miyazaki, Akira Hara, Natsuko Suzui, Hiroyuki Tomita, Kazuhiro Kobayashi, Teruaki Oka, Naoki Watanabe, Yasunori Oumi
Rok vydání: 2019
Předmět:
Zdroj: Pathology International. 69:229-234
ISSN: 1320-5463
DOI: 10.1111/pin.12772
Popis: A 73-year-old Japanese man, who worked at a confectionery company for more than 20 years, was diagnosed with a 28 mm nodular lesion in the superior lobe of the right lung by whole-body computed tomography examination. A biopsy revealed the presence of adenocarcinoma. With a diagnosis of a primary lung cancer, a right upper lobectomy was performed. A nodular lesion, 25 × 23 mm in size, was observed in the upper right lobe lung field, and was diagnosed histopathologically as a papillary adenocarcinoma. In addition, fibrous scars in the central part of the tumor showed numerous Langhans and/or foreign body giant cells, and histiocytic cells that had phagocytized numerous small transparent crystals, together with coal powder deposition. The extracted crystals were observed with a scanning electron microscope, and although plate-like structures were observed, ferruginous bodies suggestive of asbestos were not found. The crystals were demonstrated to be talc by powder X-ray diffraction. Herein, we investigated a case of lung adenocarcinoma in a patient with talcosis, with discussions based on a literature search. This collision of talcosis and lung adenocarcinoma adds to an increasing body of knowledge on an apparent association between talc and cancer cases.
Databáze: OpenAIRE
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