ChemInform Abstract: Formal Total Synthesis of Hemibrevetoxin B via the Intramolecular Allylation Followed by Ring-Closing Metathesis

Autor:	Takashi Abe, Ryoko Nagata, Isao Kadota, Abeda S. Touchy, Yukako Ishitsuka, Yoshinori Yamamoto
Rok vydání:	2008
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Ring-closing metathesis chemistry Carboxylic acid Intramolecular force Organic chemistry Total synthesis Alcohol Ether General Medicine Hemibrevetoxin B Metathesis
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
Popis:	A formal total synthesis of hemibrevetoxin B (1) is described. Intramolecular allylation of α-chloroacetoxy ether 10, prepared from carboxylic acid 11 and alcohol 12, was carried out with MgBr 2 ·OEt 2 to give 27. Ring-closing metathesis of 27 furnished tetracycle 29, which was converted to a known synthetic intermediate 9, to complete a formal total synthesis of 1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8ee20a7c8ec8b73535c6e5e6060592b0 https://doi.org/10.1002/chin.200823207 Zobrazit plný text záznamu Plný text