Alterations in plasma sialyltransferase levels in patients with neoplastic disease

Autor:	Michael D. Henderson, David Kessel
Rok vydání:	1977
Předmět:	chemistry.chemical_classification Cancer Research biology business.industry Sialyltransferase Neoplastic disease Sialyltransferase activity Enzyme Oncology chemistry Cancer research biology.protein Medicine In patient business Glycoprotein Normal control
Zdroj:	Cancer. 39:1129-1134
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(197703)39:3<1129::aid-cncr2820390318>3.0.co;2-3
Popis:	Levels of glycoprotein:sialyltransferase activity (EC 2.4.99.1; CMP-acetyl-neuraminate:D-galactosyl-glycoprotein N-acetylneuraminyl-transferase) were measured in plasma of patients with neoplastic disease, and were found elevated above normal control values in 85% of patients examined. There was a correlation between enzyme levels and course of disea-e in 46 of 57 patients studied serially during therapy. Plasma sialyltransferase may be a useful marker enzyme for monitoring effectiveness of therapeutic programs for disseminated neoplasms.
Databáze:	OpenAIRE
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