| Popis: |
Background: Whether asymptomatic chronicinternal carotid artery occlusion (CICAO) can cause cognitive impairment as well as its underlying neuroimaging alterations remain controversial. Multi-modal magnetic resonance imaging (MRI) has been extensively utilized in the study of cognitive impairment to reveal the potential brain functional or structural changes. We aim to investigate the underlying brain changes in asymptomatic CICAO patients with or without cognitive impairment by using multimodal MRI techniques. Methods: First, patients with asymptomatic CICAO will be recruited from Tangdu hospital, and individuals without CICAO will be recruited as health controls (HC) from the local community. Then, these subjects will undergo a series of neuropsychology tests focusing on the cognition and multi-modal MRI brain scans. Appropriate statistical software will be utilized to investigate the neuropsychological performance and multimodal MRI data to investigate the potential associations between cognition and the neuroimaging features in patients with asymptomatic CICAO. Discussion: In this study, multi-modal MRI will be used to evaluate the characteristics of asymptomatic CICAO. Imaging features that will be assessed include volumetric characteristics, functional characteristics and perfusion properties. Clinical information, such as basic information, age, gender, body mass index and educational level for asymptomatic CICAO will be collected for statistical analysis. Montreal Cognitive Assessment, Pittsburgh Sleep Quality Index, Self-rating Depression Scale and Self-rating Anxiety Scale will be applied to access cognition, sleep disorder, depression and anxiety, respectively. This clinical trial will help establish an effective screening system to assess cognitive impairment and the underlying neuroimaging biomarkers for asymptomatic CICAO disease. Trial registration: This study has already been registered at Clinical Trials. Gov (ID: NCT04443439) on May 27, 2020. |
