Preparation of 2H-spiro[benzo[d]isothiazole-3,3′-pyrazole]-1, 1-dioxide-2′(4′H)-carboxylates from dilithiatedC(α),N-carboalkoxyhydrazones and methyl 2-(aminosulfonyl)benzoate

Autor:	Don VanDerveer, Anna C. Dawsey, Clyde R. Metz, Andrew J. Puciaty, Chandra Potter, Ellyn A. Smith, Amanda M. Acevedo-Jake, Charles F. Beam, William T. Pennington, Zachary C. Kennedy, John D. Knight
Rok vydání:	2009
Předmět:	Acetic anhydride chemistry.chemical_compound Isothiazole chemistry Organic Chemistry Condensation Pyrazole Medicinal chemistry Combinatorial chemistry
Zdroj:	Journal of Heterocyclic Chemistry. 46:231-236
ISSN:	1943-5193 0022-152X
Popis:	A variety of substituted spiro(benzoisothiazole-pyrazoles) have been prepared by the condensation of dilithiated C(α),N-carboalkoxyhydrazones with lithiated methyl 2-(aminosulfonyl)benzoate followed by the cyclization of intermediates with acetic anhydride, which also resulted in spiro N-acetylated products when carbomethoxyhydrazones or carboethoxyhydrazones were used, and spiro NH products when carbo-tert-butoxyhydrazones were used. J. Heterocyclic Chem., 46, 231 (2009).
Databáze:	OpenAIRE
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