Methods and fiber optics spectrometry system for control of photosensitizer in tissue during photodynamic therapy
| Autor: | Oksana M. Chepurna, Olexiy Azarov, Damian Harasim, Irina Shton, V.V. Kholin, Sergii V. Pavlov, Gamaleia Nf, Valerii S. Voytsehovich |
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| Rok vydání: | 2016 |
| Předmět: |
Optical fiber
Materials science medicine.medical_treatment Photodynamic therapy Radiation Laser Mass spectrometry Fluorescence Signal law.invention 03 medical and health sciences 0302 clinical medicine law 030220 oncology & carcinogenesis medicine 030211 gastroenterology & hepatology Photosensitizer Biomedical engineering |
| Zdroj: | Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2016. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.2249259 |
| Popis: | Photodynamic cancer therapy is used as an alternative or in combination with conventional treatments. PDT involves three key components: a photosensitizer, a light source and tissue oxygen. The combination of these three components leads to the chemical destruction of any tissues which have either selectively taken up the photosensitizer or have been locally exposed to light. In our research we used Charge-coupled device (CCD) spectrometers to measure intensity of the fluorescence signal. Devices allow receiving and processing signal in a CCD structure at a wide range of wavelengths. We have established a system for measuring the fluorescence of tumor tissue. These results are important for determining the dose of laser radiation and optimal time for laser action without damaging healthy tumor. |
| Databáze: | OpenAIRE |
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