[P194] Breast cancer radiosurgery with a synchrotron radiation beam
| Autor: | Gabriela Hoff, Giovanni Mettivier, Francesca Di Lillo, Riccardo Calandrino, Guido Cavaletti, Gabriella Nicolini, Bruno Golosio, Claudio Fiorini, Paolo Russo, Marica Masi, M. Cattaneo, Cecilia Ceresa, Antonio Brunetti, Viviana Fanti, Anton io Sarno |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
business.industry medicine.medical_treatment Biophysics General Physics and Astronomy Synchrotron radiation General Medicine medicine.disease Radiosurgery Imaging phantom Collimated light 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis medicine Radiology Nuclear Medicine and imaging Irradiation Nuclear medicine business Beam (structure) |
| Zdroj: | Physica Medica. 52:156 |
| ISSN: | 1120-1797 |
| Popis: | Purpose Recently, we proposed the use of the synchrotron radiation (SR) beam for a new rotational radiotherapy technique for breast cancer treatment (SR3T) [1] ;. In this work, we show, via Monte Carlo (MC) simulations, the potential of SR3T also for application in breast radiosurgery with the patient in prone position. Methods We simulated the irradiation condition of the breast rotational radiosurgery with a MC code based on GEANT 4 toolkit. The pendant breast was modeled as a polyethylene cylinder with a diameter of 14 cm and height of 9 cm with a 1-cm tumor simulated in the centre or at 4 cm from the cylinder axis. A monoenergetic laminar SR beam of size 1.5 cm × 1.0 cm with energy ranging between 60 and 120 keV irradiated the phantom during a complete rotation with the center of rotation along the tumor mass. Results A collimated SR beam irradiating a pendant breast produces a dose distribution peaked at the center of rotation. MC simulations showed that is possible to perform partial-breast irradiation with a skin sparing comparable with that from a conventional MV breast radiotherapy. Conclusions We proposed a kV SR beam for partial-breast irradiation, for breast radiosurgery in the treatment of small lesions. We foresee the use of dose-enhancement agents in order to improve the dose to the target volume with proper sparing of healthy tissues. |
| Databáze: | OpenAIRE |
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