| Popis: |
A novel metformin hydrochloride sustained-release suspension containing ion exchange resin as carriers have been reported in a previous study. In the present study, the pharmacokinetics of this sustained-release suspension in beagle dogs was investigated. A high performance liquid chromatography (HPLC) method was established to detect the amount of metformin hydrochloride in vivo. The pharmacokinetics parameters of the metformin hydrochloride sustained-release suspension and a reference metformin hydrochloride tablet were: AUC0~24(μg·h·ml-1) 72.94 and 78.07, Cmax (μg·ml-1) 7.97 and 15.42, Tmax (h) 4.2 and 1.83 respectively. The results indicated that the suspension was bioequivalent with the reference tablet, and had an obvious sustained-release effect. Keywords: Metformin hydrochloride, sustained-release, ion exchange resin, in vivo, pharmacokinetics. |
