The Anticomplementary Activity of Serum Gamma Globulin
| Autor: | Bernard D. Davis, Elvin A. Kabat, Ad Harris, Dan H. Moore |
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| Rok vydání: | 1944 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 49:223-233 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.49.4.223 |
| Popis: | Summary Electrophoretically separated gamma globulin from a number of normal human sera was highly anticomplementary, as little as 0.04 mg of protein giving complete inhibition of hemolysis under the conditions used. Purified Wassermann antibody, prepared by dissociation of the specific precipitate, was anticomplementary in similar amounts. The anticomplementary action was decreased by heating at 56 C for ½ hour, and was abolished by addition of approximately equal amounts of albumin or beta globulin. It is suggested that the data offer the first evidence of an easily dissociable compound between complement and antibody, postulated by Heidelberger, Weil, and Treffers in their theory of the mechanism of complement fixation. |
| Databáze: | OpenAIRE |
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