Understanding and Controlling the Formation of an N-Alkyl Impurity in Olmesartan Medoxomil: A Derivative via Michael-Type Addition between Tetrazole and Mesityl Oxide In Situ Generated from Acetone
| Autor: | Wang Yinquan, Yuan Shun, Wu Taizhi, Li Xiao, Shi Yinfei, Liang Xiaomin, Lu Jianwu |
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| Rok vydání: | 2021 |
| Předmět: |
Active ingredient
chemistry.chemical_classification 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Mesityl oxide Impurity Polymer chemistry medicine Acetone Tetrazole Physical and Theoretical Chemistry Olmesartan Alkyl Derivative (chemistry) medicine.drug |
| Zdroj: | Organic Process Research & Development. 25:1112-1122 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.0c00506 |
| Popis: | An unknown impurity was detected in olmesartan medoxomil active pharmaceutical ingredient (API), which was determined as 2-methyl-4-oxopentan-2-yl-protected olmesartan medoxomil by NMR and mass spe... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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