An Improved Scalable Process for the Synthesis of (S,S)-DACH-Ph Trost Ligand

Autor:	Yongda Zhang, Eugene Chong, Jada A. H. White, Suttipol Radomkit, Yibo Xu, Stephanie C. Kosnik, Jon C. Lorenz
Rok vydání:	2022
Předmět:	Organic Chemistry
Zdroj:	Synlett. 33:1287-1289
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0041-1738371
Popis:	An improved chemical process has been developed for the synthesis of (S,S)-DACH-Ph Trost ligand. The amidation of 2-diphenylphosphinylbenzoic acid and (S,S)-diaminocyclohexane is promoted by stoichiometric CDI and catalytic imidazole hydrochloride. The resulting product, (S,S)-DACH-Ph Trost ligand, is isolated as a white solid in 80% yield with >99% ee by simple filtration without column chromatography. The current facile process is also demonstrated on kilogram scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8ea26922cd03974979d930d1d8b3f800 https://doi.org/10.1055/s-0041-1738371 Zobrazit plný text záznamu