The Polymerization of Pharmacophoric Moieties and Its Effect Upon Biologic Activity I. Polymeric Quaternary Ammonium Salts**Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City

Autor:	H. H. Keasling, F.W. Schueler
Rok vydání:	1956
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Polymerization chemistry Yield (chemistry) Organic chemistry Ammonium Polymer Ammonium compounds
Zdroj:	Journal of the American Pharmaceutical Association (Scientific ed.). 45:792-796
ISSN:	0095-9553
DOI:	10.1002/jps.3030451207
Popis:	A group of polymeric quaternary ammonium salts have been synthesized and studied pharmacologically. The polymers exhibited a high degree of neuromuscular blocking potency. The results have been discussed both in regard to their theoretic and practical importance. Such polymers exemplify the idea that multiplication of pharmacophoric moieties through polymerization may yield drug agents having very long durations of action.
Databáze:	OpenAIRE
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