Radiochemical and Biological Evaluation of 99mTc-Labeling of Phthalic Acid Using 99mTc-Tricabonyl and 99mTc-Sn (II) As a Model for Potential Hazards Imaging
| Autor: | Ibrahim It, M. H. Sanad, Fouzy Asm, Saad Mm, F. A. Marzook |
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| Rok vydání: | 2016 |
| Předmět: |
Chromatography
Reducing agent business.industry In vivo toxicity 010501 environmental sciences 010403 inorganic & nuclear chemistry Bioinformatics 01 natural sciences In vitro 0104 chemical sciences Phthalic acid chemistry.chemical_compound chemistry Yield (chemistry) Medicine Bio distribution business Technetium-99m 0105 earth and related environmental sciences Biological evaluation |
| Zdroj: | Journal of Molecular Imaging & Dynamics. |
| ISSN: | 2155-9937 |
| Popis: | In this study, 99mTc- phthalic acid (PA) firstly, was prepared with a high radiochemical yield up to 98% that confirmed with different chromatographic techniques by using 2 mg phthalic acid, 50 μg SnCl2·2H2O as a reducing agent, in solution of pH 7 at room temperature for 30 min. Secondly, 99mTc-tricarbonyl phthalic acid was prepared under 30 min heating at 100°C. Bio distribution studies were carried out in Albino Swiss mice in which 99mTc-PA and 99mTc-tricarbonyl PA were concentrated in kidneys and intestine. This work aims to evaluation of labeled PA as a model for Potential Hazards imaging in vitro and in vivo toxicity in Albino Swiss mice. |
| Databáze: | OpenAIRE |
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