Brain Diffusion Imaging and Tractography to Distinguish Clinical Severity of Human PLP1-Related Disorders
Autor: | Bruno Pereira, Catherine Sarret, Anna Sontheimer, Jean-Jacques Lemaire, Odile Boespflug-Tanguy, Bastien Roche, Nadia Savy, Jerome Coste |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.diagnostic_test business.industry Pelizaeus–Merzbacher disease Magnetic resonance imaging Anatomy Grey matter Commissure medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Superior cerebellar peduncle medicine.anatomical_structure Developmental Neuroscience Neurology Fractional anisotropy medicine business 030217 neurology & neurosurgery Tractography Diffusion MRI |
Zdroj: | Developmental Neuroscience. 40:301-311 |
ISSN: | 1421-9859 0378-5866 |
DOI: | 10.1159/000492218 |
Popis: | Aims: We performed quantitative diffusion tensor imaging and brain tractography to distinguish clinical severity in a series of 35 patients with hypomyelinating PLP1-related disorders classified using the Motor Developmental Score according to the best motor function acquired before the age of 5 years and the gross motor function measure (GMFM) at the time of magnetic resonance imaging acquisition. Methods: We calculated fractional anisotropy and diffusivity values in 26 regions of interest and the numbers of fibers and volumes of hemisphere tractograms. Fiber bundles on tractograms were characterized according to 3 criteria: size, direction of main-stream fibers, and connectivity of bundles (extratelencephalic projections, commissural fibers, and intrahemispheric connections). Results: Age-adjusted multivariate analysis in 3 severity groups revealed increased isotropic diffusion in the superior cerebellar peduncle and grey matter in the most severe group, and larger tractogram volumes and increased numbers of fibers in the least severely affected group. Tractogram patterns showed preserved extratelencephalic projections and a main anterior-posterior aspect of intrahemispheric fibers in most patients, whereas interhemispheric connectivity was variable. The most severely affected and intermediate patients had less intrahemispheric connectivity, with a frequent predominant anterior-posterior direction of main-stream fibers. Interpretation: Diffusion tensor imaging and tractographic parameters can operate as biomarkers to distinguish clinical severity in PLP1-related disorders and could improve our understanding of hypomyelinating leukodystrophies. |
Databáze: | OpenAIRE |
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