Practical way for the synthesis of 3,3′-bis-substituted benzo[d][1,2]oxaphosphole 2-oxides by phosphonylation of in situ generated o-quinone methides

Autor:	Feijun Wang, Xinchun He, Wenwen Lv, Min Shi, Xiaomeng Shi, Hao Wei
Rok vydání:	2018
Předmět:	Steric effects In situ 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry O quinones 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Acetic anhydride Nucleophile Reagent Drug Discovery Phenol Hydroxymethyl
Zdroj:	Tetrahedron Letters. 59:1038-1041
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2018.01.093
Popis:	Phosphonylation of the pretreated 2-(hydroxymethyl)phenol derivatives with acetic anhydride using trialkylphosphites as the nucleophilic reagents was reported, providing a practical way to the synthesis of novel highly steric 3,3′-bis-substituted benzo[d][1,2]oxaphosphole 2-oxides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8e985304257646de56c52f3e20799d5c https://doi.org/10.1016/j.tetlet.2018.01.093 Zobrazit plný text záznamu Full Text from ScienceDirect