What is the normal composition of pericardial fluid?
| Autor: | Maria del Carmen Baigorria Vaca, Caterina Simon, Massimo Imazio, Silvia Maestroni, Sabrina Buoro, Giulia Previtali, Yehuda Adler, Ferruccio Ceriotti, Diego Cugola, Valentina Moioli, Michela Seghezzi, Barbara Manenti, Francesco Innocente, Enrico Tombetti, Antonio Brucato |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cholesterol business.industry Albumin Pericardial fluid Venous blood 030204 cardiovascular system & hematology Gastroenterology Transudate Reference intervals 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Lactate dehydrogenase Internal medicine Medicine Composition (visual arts) Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart. 107:1584-1590 |
| ISSN: | 1468-201X 1355-6037 |
| DOI: | 10.1136/heartjnl-2020-317966 |
| Popis: | ObjectiveBiochemical and cytological pericardial fluid (PF) analysis is essentially based on the knowledge of pleural fluid composition. The aim of the present study is to identify reference intervals (RIs) for PF according to state-of-art methodological standards.MethodsWe prospectively collected and analysed the PF and venous blood of consecutive subjects undergoing elective open-heart surgery from July 2017 to October 2018. Exclusion criteria for study enrolment were evidence of pericardial diseases at preoperatory workup or at intraoperatory assessment, or any other condition that could affect PF analysis.ResultsThe final study sample included 120 patients (median age 69 years, 83 men, 69.1%). The main findings were (1) High levels of proteins, albumin and lactate dehydrogenase (LDH), but not of glucose and cholesterol (2) High cellularity, mainly represented by mesothelial cells. RIs for pericardial biochemistry were: protein content 1.7–4.6 g/dL PF/serum protein ratio 0.29–0.83, albumin 1.19–3.06 g/dL, pericardium-to-serum albumin gradient 0.18–2.37 g/dL, LDH 141–2613 U/L, PF/serum LDH ratio 0.40–2.99, glucose 80–134 mg/dL, total cholesterol 12–69 mg/dL, PF/serum cholesterol ratio 0.07–0.51. RIs for pericardial cells by optic microscopy were: 278–5608 × 106 nucleated cells/L, 40–3790 × 106 mesothelial cells/L, 35–2210 × 106 leucocytes/L, 19–1634 × 106 lymphocytes/L.ConclusionsPF is rich in nucleated cells, protein, albumin, LDH, at levels consistent with inflammatory exudates in other biological fluids. Physicians should stop to interpret PF as exudate or transudate according to tools not validated for this setting. |
| Databáze: | OpenAIRE |
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