Advances in Drug Delivery to Cancer Patients: Introduction

Autor: L. Domellöf
Rok vydání: 1990
Předmět:
Zdroj: Progress in Regional Cancer Therapy ISBN: 9783642748202
DOI: 10.1007/978-3-642-74818-9_1
Popis: The targeted delivery of cytotoxic drugs to cancer patients is intended to optimize therapeutic efficacy and reduce side effects. Early results from pioneer work in Boston using a clockwork drive were positive and led to development of the Chronometric Infusor [2]. This external pump was linked to a percutaneous arterial or venous catheter. It was carried in a foam-rubber pouch to dampen the ticking of the clockwork and attached by straps around the patient’s neck and chest. The plastic drug reservoir of the pump had a capacity of 25 ml, and the system allowed a delivery rate of 5 ml per 24 h. The clockwork required winding after 8–12 h.
Databáze: OpenAIRE
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