Synthesis of 1-Acyl-2-vinylcyclopropanes: Utilizing Copper-Carbenoid versus Sulfur Ylide Methodology
| Autor: | Anna Zens, Benedikt Kolb, Birgit Claasen, Philipp Seubert, Doris Kunz, Fabian Mannchen, Robert Forschner, Marcel Holzwarth, Marius Wurster, Sabine Laschat |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Cyclopropanation Alkene Aryl Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Combinatorial chemistry Sulfur Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Ylide Moiety Carbenoid Alkyl |
| Zdroj: | Synthesis. 50:2367-2384 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0036-1591554 |
| Popis: | The synthesis of a range of racemic 1-acyl-2-vinylcyclopropanes by using two different methodologies is studied. We have developed a copper-catalyzed process for converting diazoketones into 1-acyl-2-vinylcyclopropanes and a sulfur-ylide-mediated procedure which allows, in only two steps, a simplified access to 1-acyl-2-vinylcyclopropanes with alkyl or aryl substituents on the alkene moiety. |
| Databáze: | OpenAIRE |
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