| Popis: |
Despite the recent development of new, promising strategies for melanoma, therapy resistance and tumor relapse remained major problems. As therapeutic strategies particularly aim at an induction of apoptosis, deficient proapoptotic signaling appears as a critical issue of therapy resistance. Thus, strategies to sensitize melanoma cells for proapoptotic signals are highly relevant. Extrinsic (death receptor-mediated) and intrinsic (mitochondria-mediated) proapoptotic pathways have been described; and the better understanding how proapoptotic pathways are blocked in melanoma, will show the direction for the development of more efficient combination therapies. |
