DETECTION OF RESIDUAL LUNG CANCER CELLS BY PCR-BASED GENETIC TESTING FOR ROS1-TRANSLOCATION: CASE REPORT

Autor: Natalya Mityushkina, Yevgeniy Imyanitov, Yevgeniy Levchenko, Fedor Moiseenko, Nikita Levchenko, Vladislav Tyurin, Aglaya Ievleva
Rok vydání: 2018
Předmět:
Zdroj: Problems in oncology. 64:331-334
ISSN: 0507-3758
Popis: A patient with lung cancer carrying ROS1 translocation was treated by crizotinib and then subjected to surgery. Morphological analysis revealed pathologic complete response in surgically removed tissues, while PCR test provided convincing evidence for the presence of residual tumor cells. PCR analysis of lung cancer specific gene translocations allows carrying out highly sensitive and reliable monitoring of tumor disease during the course of treatment.
Databáze: OpenAIRE