Effect of Structure of 1-Substituted Isatins on Direction of Their Reactions with Some Acetohydrazide Ammonium Derivatives

Autor:	A. S. Sapunova, Andrei V. Bogdanov, A. D. Voloshina, N. V. Kulik, Vladimir F. Mironov
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Isatin Substituent Moderate activity General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Nitrogen atom Reagent Aromatic fragment Side chain Ammonium
Zdroj:	Russian Journal of General Chemistry. 90:1591-1600
ISSN:	1608-3350 1070-3632
Popis:	The reaction of 1-acylisatins with Girard’s reagent T proceeds with elimination of the acyl substituent and the formation of isatin-3-hydrazone with a quaternary nitrogen atom in the side chain. Depending on the structure of the substituent in position 1, 1-(aminomethyl)isatins reacted with the Girard’s reagent T to form hydrazones either with the elimination of the aminomethyl substituent or with its retention. Isatin derivatives containing no substituents in the aromatic fragment exhibit moderate activity against gram-positive bacteria S. aureus 209p and B. cereus 8035. Low hemotoxicity of the obtained compounds was revealed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8e746e83dd7b166ff8556457975ca786 https://doi.org/10.1134/s1070363220090029 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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