Intestinal adaptation in short bowel syndrome

Autor:	E. Heineman, Cornelius H. C. Dejong, Carlo F. M. Welters, Nicolaas E. P. Deutz
Rok vydání:	2002
Předmět:	Programmed cell death medicine.medical_specialty Gastrointestinal tract business.industry Crypt General Medicine Short bowel syndrome medicine.disease Enteral administration Gastroenterology Parenteral nutrition Apoptosis Internal medicine Medicine Surgery business Barrier function
Zdroj:	ANZ Journal of Surgery. 72:229-236
ISSN:	1445-1433
DOI:	10.1046/j.1445-2197.2002.02357.x
Popis:	Regaining enteral autonomy after extensive small bowel resection is dependent on intestinal adaptation. This adaptational process is characterized by hyperplastic growth of the remaining gut, which is accompanied by both an increase of cell division at the level of the crypt cells and by an increased rate of programmed cell death (apoptosis). Apart from the absorptive function, the small bowel also has a barrier function and plays an important role in interorgan metabolism. Also, these functions are greatly affected by a massive intestinal resection and subsequent recovery by intestinal adaptation. This review aims to give an overview of the debilitating effects of massive intestinal resection on gut function and subsequently discusses intestinal adaptation and possible factors stimulating adaptation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8e6ff66955ad0b0827deb3ff2225781d https://doi.org/10.1046/j.1445-2197.2002.02357.x Zobrazit plný text záznamu Plný text