| Autor: |
M. K. Njenga, A. Matsumori, J. K. Gwathmey |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Developments in Cardiovascular Medicine ISBN: 9781461348658 |
| DOI: |
10.1007/978-1-4419-9264-2_24 |
| Popis: |
Myocarditis in humans is often subclinical and difficult to recognize,1 limiting our full appreciation of the natural history and potential progression of the disease to chronic cardiomyopathy. Searching for a suitable animal model we studied the cardiovascular effects of infection of young pigs with a cardiotropic strain of encephalomyocarditis virus. This model was found to closely resemble viral myocarditis in humans in the acute as well as subacute and chronic phases. The pig was selected because of similarities in cardiac anatomy and physiology as well as the technical ease of making clinical observations, including noninvasive echocardiography and electrocardiography. This chapter presents an overview of our experience with this model establishing its usefulness for further studies of the natural history and pathophysiology of viral myocarditis |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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