Comparative Electron-Microscopic Study of the Erythrocytic Line in Refractory Anemia (Preleukemia) and Myelomonocytic Leukemia

Autor:	J. Maigne, D. Lecoq, J. E. Maldonado
Rok vydání:	1977
Předmět:	Pathology medicine.medical_specialty Myelomonocytic leukemia business.industry Preleukemia Refractory anemia medicine.disease Lesion Leukemia medicine.anatomical_structure Normoblast hemic and lymphatic diseases medicine Bone marrow medicine.symptom business Electron microscopic
Zdroj:	Hemopoietic Dysplasias (Preleukemic States) ISBN: 9783540075974
DOI:	10.1007/978-3-642-66312-3_12
Popis:	The bone marrow erythrocytic precursors of 12 patients with refractory anemia (preleukemia) or myelomonocytic leukemia were studied by transmission electron microscopy. The results were tabulated in a semiquantitative manner and a comparison was established between the two main diagnostic groups. The following results are reported. 1. Similar nuclear and cytoplasmic abnormalities of the normoblasts were observed in preleukemia and leukemia. 2. A nuclear lesion consisting of nuclear clefts and blebs was demonstrated in at least some of the normoblasts in all of the patients. Although not specific, this finding appears to be a new contribution in the field of preleukemia and myelomonocytic leukemia. 3. Iron overload, including the presence of pathologic sideroblasts, is common to both preleukemia and leukemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8e657a2d0cc2eb0f2567ef085ba38431 https://doi.org/10.1007/978-3-642-66312-3_12 Zobrazit plný text záznamu