| Autor: |
Ugo Castelli, Jérôme Marrot, Sébastien Thibaudeau, Omar Karam, Fodil Bouazza, Alexandre Le Darz, Agnès Martin-Mingot, Naima Mokhtari |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
ChemInform. 47 |
| ISSN: |
0931-7597 |
| DOI: |
10.1002/chin.201622042 |
| Popis: |
An efficient and straightforward regio-controlled route to β-fluoro-γ-chlorinated amines was developed via an ammonium–chloronium superelectrophilic activation in superacid HF/SbF5. Through halogen directing effect the method was extended to a variety of (poly)halofluorinated building blocks amenable for further synthetic modifications. The direct synthesis of chlorofluorinated analogues of bioactive compounds via this process confirmed the ability to use this strategy for further applications in medicinal chemistry. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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