Study of vitamin E response on chronic hepatitis C patients under inter feron plus Ribavirin therapy
| Autor: | Said El Hendawy, Mohammed El Desouky, Salwa El Hadad, Ashraf R. Abulfutuh, Moemena Kamel, Mohammed Morsy, Abd El Ghany Solyman |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Hepatology business.industry Ribavirin Vitamin E medicine.medical_treatment Gastroenterology Placebo medicine.disease Placebo group chemistry.chemical_compound symbols.namesake chemistry Chronic hepatitis Internal medicine medicine Every Two Months symbols Viral hepatitis business Fisher's exact test |
| Zdroj: | Gastroenterology. 124:A768 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/s0016-5085(03)83878-7 |
| Popis: | Background:Interferon-alpha plus Ribavirin is the treatment of choice in patients with chronic hepalitis C(CHC); un{brtunately , t~ulya minority of patients have a sustained response .Aim and Methods:We conducted a randomised-placebo control study to evaluate the effect of \fltamin E after IFN-alpha plus Ribavirin therapy on the durability, of the biochemical and virological response Serum HCV-RNA , ALT and Vitamin E were determined every two months lor 48 weeks The 126 CHC patients enrolled were treated with 6MU recombinant 1FN-alpha2a thrice/week plus Ribav~irin (1,200 my/day) for 6 months. Results :after six momhs of antiviral therapy , 66 patients were non responders and 16 patients presented intolerance to therapy ; the remainders 44 responder patients randomly received either Vitamin E (900 mgJday) or placebo tot 6 months .in the Vitamin E group, 20 out of 22 patients (91%) showed the persiste~me of complete response m therapy, one patient had serum HCV-RNA but normal AI_T at the tiourffi month and one patient relapsed at the second month .In the Placebo group subjects presenting a complete sustained response were oNy 13 (59%), 7 patients relapsed after 2 month from antiviral therapy and 2 patients showed HCV-RNA but normal ALT, Conclusion : a long-term Vitamm E administration significantly (p |
| Databáze: | OpenAIRE |
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