Synthesis of Internal Alkynes through the Pd-Catalyzed Coupling of Heteroaryl Halides with Terminal Alkynes

Autor:	Yan Zhu, Jincheng Mao, Hailong Yang, Hong Yan, Linhua Lu, Guangwei Rong, Peng Sun, Defu Liu
Rok vydání:	2013
Předmět:	Terminal (electronics) chemistry Organic Chemistry chemistry.chemical_element Surface modification Organic chemistry Halide Physical and Theoretical Chemistry Combinatorial chemistry Palladium Catalysis
Zdroj:	European Journal of Organic Chemistry. 2013:1644-1648
ISSN:	1434-193X
DOI:	10.1002/ejoc.201201689
Popis:	Sonogashira-type cross-couplings of functionalized heterocyclic halides with terminal alkynes were performed efficiently at room temperature. The heteroaryl halides were easily prepared from the corresponding heterocyclic compounds. The catalytic system tolerated a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. This reaction provides an efficient method for the direct functionalization of heterocycles.
Databáze:	OpenAIRE
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