Synthesis of mixed acyclic imides using pentafluorophenyl esters

Autor:	Wenbao Li, Merritt B. Andrus, Robert F. Keyes
Rok vydání:	1998
Předmět:	chemistry.chemical_compound Primary (chemistry) chemistry Yield (chemistry) Amide Organic Chemistry Drug Discovery Lactam Organic chemistry Pentafluorophenyl esters Sodium hexamethyldisilazide Biochemistry
Zdroj:	Tetrahedron Letters. 39:5465-5468
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)01112-5
Popis:	Mixed acyclic imides are assembled using amide anions and pentafluorophenyl esters reacted in THF at low temperature. Sodium hexamethyldisilazide deprotonates lactam 4 followed by addition of pentafluorophenyl (PFP) esters to give imides in high yield (85–90%). Acyclic TMS-protected primary amides were also reacted under basic conditions with PFP esters to give mixed imides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8e480b8d56c5f038de400a10f4010629 https://doi.org/10.1016/s0040-4039(98)01112-5 Zobrazit plný text záznamu Full Text from ScienceDirect