Development of a Dosage Form of the New Antitumor Antibiotic Olivamide

Autor:	Anna N. Tevyashova, Andrey E. Shchekotikhin, E. N. Bychkova, Lyubov G. Dezhenkova
Rok vydání:	2019
Předmět:	Pharmacology Drug 010405 organic chemistry medicine.drug_class Chemistry media_common.quotation_subject Antibiotics Pharmacology toxicology 01 natural sciences Olivomycin A Dosage form 0104 chemical sciences 010404 medicinal & biomolecular chemistry High specific activity Drug Discovery medicine media_common
Zdroj:	Pharmaceutical Chemistry Journal. 52:930-935
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-019-01928-x
Popis:	Methods for selective chemical modification of the antitumor antibiotic olivomycin A(OA) were developed at GINA. The compound olivamide with advantages over starting OA was selected from series of OA analogs. The goal of the present work was to develop a dosage form of the antitumor semi-synthetic antibiotic olivamide that guaranteed the stability and high specific activity of olivamide drug substance and was designed for further comprehensive preclinical studies.
Databáze:	OpenAIRE
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