| Popis: |
Fish oil is a rich source of long-chain omega-3 polyunsaturated fatty acids (LCn-3 PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Over the past threedecades, a converging body of evidence has implicated dietary deficiency in LCn-3 PUFAs in the pathophysiology and etiology of major depressive disorder (MDD), and that fish oil supplementation reduces depressive symptoms. Recently emerging neuroimaging evidence further suggests fish oil supplementation promotes neuronal resilience and white-matter integrity. Translational evidence suggests elevated proinflammatory signaling, deficits in cerebral perfusion and glucose utilization, and synaptic regression may mediate the association between LCn-3 PUFA insufficiency and central pathological processes implicated in MDD. Together, this body of evidence provides a strong rationale for identifying and treating LCn-3 PUFA deficiency in patients with or at risk for MDD in a broader effort to optimize treatment and improve long-term health outcomes for patients. |
