Structural properties of fracture haematoma: current status and future clinical implications
| Autor: | Yin Xiao, Vaida Glatt, Thor Friis, Xin Wang, Ross Crawford |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty biology business.industry Growth factor medicine.medical_treatment fungi Biomedical Engineering Medicine (miscellaneous) Fracture site Bone fracture medicine.disease Bone defect Fibrin Biomaterials Cellular infiltration 03 medical and health sciences 030104 developmental biology biology.protein Medicine Platelet business Bone regeneration Biomedical engineering |
| Zdroj: | Journal of Tissue Engineering and Regenerative Medicine. 11:2864-2875 |
| ISSN: | 1932-6254 |
| Popis: | Blood clots (haematomas) that form immediately following a bone fracture have been shown to be vital for the subsequent healing process. During the clotting process, a number of factors can influence the fibrin clot structure, such as fibrin polymerization, growth factor binding, cellular infiltration (including platelet retraction), protein concentrations and cytokines. The modulation of the fibrin clot structure within the fracture site has important clinical implications and could result in the development of multifunctional scaffolds that mimic the natural structure of a haematoma. Artificial haematoma structures such as these can be created from the patient's own blood and can therefore act as an ideal bone defect filling material for potential clinical application to accelerate bone regeneration. Copyright © 2016 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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