Nosocomial spread of Klebsiella pneumoniae isolates producing blaGES-4 carbapenemase at a Japanese hospital
| Autor: | Katsutoshi Yamasaki, Kaneyuki Kida, Kaori Satoh, Tamaki Orita, Tetsu Mizutani, Takuya Zikimoto, Noriyuki Sueyoshi, Isako Nakai, Masaru Komatsu, Hirofumi Toda, Tomomi Kofuku, Isao Nishi, Tamotsu Ono, Yasunao Wada, Masahiro Akagi, Tatsuya Nakamura, Hisaaki Nishio |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) biology medicine.drug_class Klebsiella pneumoniae 030106 microbiology Cephalosporin Tertiary care hospital biology.organism_classification Virology respiratory tract diseases Microbiology 03 medical and health sciences Infectious Diseases Plasmid medicine Pharmacology (medical) Cephamycins General hospital |
| Zdroj: | Journal of Infection and Chemotherapy. 23:40-44 |
| ISSN: | 1341-321X |
| DOI: | 10.1016/j.jiac.2016.09.006 |
| Popis: | Six Klebsiella pneumoniae clinical isolates resistant to various cephalosporins and cephamycins were identified in a Japanese general hospital, a tertiary care hospital, between November 2009 and April 2010. All K. pneumoniae isolates carried blaGES-4 and blaSHV-1, while 2 K. pneumoniae isolates also harbored blaCTX-M-15. The pulsed-field gel electrophoresis patterns revealed that these 6 K. pneumoniae isolates were almost identical, suggesting their clonal relatedness. Plasmid profiles and conjugation assays revealed that these blaGES-4 genes were located on similar conjugative plasmids. These data indicate that nosocomial spread caused by K. pneumoniae isolates producing blaGES-4 carbapenemase occurred at a Japanese general hospital. K. pneumoniae isolate harboring blaGES-4 is rarely reported in Japan, and, to the best of our knowledge, this is the second report of K. pneumoniae isolates harboring blaGES-4 that occurred nosocomial spread in Japan. |
| Databáze: | OpenAIRE |
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