Bone marrow failure and myelofibrosis in a case of PVP storage disease

Autor:	Ming J. W. Chang, Chien-Feng Sun, Lee-Yung Shih, Tseng-tong Kuo, Po-Nan Wang, Po Dunn
Rok vydání:	1998
Předmět:	Pathology medicine.medical_specialty business.industry Pathologic fracture Bone marrow failure Arthritis macromolecular substances Hematology medicine.disease medicine.anatomical_structure Spinal cord compression medicine Bone marrow business Myelofibrosis Infiltration (medical) Polyneuropathy
Zdroj:	American Journal of Hematology. 57:68-71
ISSN:	1096-8652 0361-8609
DOI:	10.1002/(sici)1096-8652(199801)57:1<68::aid-ajh12>3.0.co;2-5
Popis:	"PVP storage disease" is a disorder occurring in patients who have received high molecular weight polyvinylpyrrolidone (PVP), which cannot be excreted from the body. These large polymers deposit in the histiocytes and cause proliferation and infiltration of histiocytes in the reticuloendothelial system. There was usually no significant damage to these organs except that prolonged administration might cause bone destruction, skin lesions, arthritis, and polyneuropathy. We describe a patient who had received a large amount of PVP-containing solution for years. Severe bone marrow failure with extensive infiltration of bone marrow by foamy histiocytes occurred later. In addition, she suffered from multiple pathological fractures with spinal cord compression and arthritis of bilateral knee joints.
Databáze:	OpenAIRE
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