Effects of salicylate and γ-resorcylate (2:6-dihydroxybenzoate) on pathways of glucose metabolism in the human red cell

Autor:	J.A. Sturman, M.J.H. Smith
Rok vydání:	1966
Předmět:	Pharmacology Hexokinase Dehydrogenase Metabolism Pentose phosphate pathway Biology Carbohydrate metabolism Biochemistry Phosphofructokinase activity chemistry.chemical_compound chemistry Lactate dehydrogenase Glycolysis
Zdroj:	Biochemical Pharmacology. 15:1857-1865
ISSN:	0006-2952
DOI:	10.1016/0006-2952(66)90092-x
Popis:	Salicylate and γ-resorcylate, in concentrations ranging from 2 to 20 mM, exert multiple effects on the metabolism of radioactive glucose by mature human erythrocytes. The drugs interfere with glycolytic reactions, inhibiting hexokinase and lactate dehydrogenase activities, and with the pentose phosphate pathway by inhibiting glucose-6-phosphate dehydrogenase activity. γ-Resoreylate (10 and 20 mM) but not salicylate, inhibits phosphofructokinase activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8e21462e2f03354a52f5f2943182cc7f https://doi.org/10.1016/0006-2952(66)90092-x Zobrazit plný text záznamu