Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys
| Autor: | Makoto Okazaki, John T. Potts, Kenji Adachi, Hiroshi Noda, Miho Nagayasu, Thomas J. Gardella, Masaru Shimizu, Tomoyuki Watanabe, Tatsuya Tamura, Eri Joyashiki, Yoshiki Kawabe |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Calcium metabolism endocrine system medicine.medical_specialty business.industry Parathyroid hormone receptor Endocrinology Diabetes and Metabolism Parathyroid hormone 030209 endocrinology & metabolism medicine.disease Bone resorption 03 medical and health sciences Hyperphosphatemia 030104 developmental biology 0302 clinical medicine Endocrinology Hypoparathyroidism Internal medicine Medicine Orthopedics and Sports Medicine Hypercalciuria business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Journal of Bone and Mineral Research. 31:1405-1412 |
| ISSN: | 0884-0431 |
| DOI: | 10.1002/jbmr.2811 |
| Popis: | Hypoparathyroidism is a disease of chronic hypocalcemia and hyperphosphatemia due to a deficiency of parathyroid hormone (PTH). PTH and analogs of the hormone are of interest as potential therapies. Accordingly, we examined the pharmacological properties of a long-acting PTH analog, [Ala(1,3,12,18,22) , Gln(10) ,Arg(11) ,Trp(14) ,Lys(26) ]-PTH(1-14)/PTHrP(15-36) (LA-PTH) in thyroparathyroidectomized (TPTX) rats, a model of HP, as well as in normal monkeys. In TPTX rats, a single intravenous administration of LA-PTH at a dose of 0.9 nmol/kg increased serum calcium (sCa) and decreased serum phosphate (sPi) to near-normal levels for longer than 48 hours, whereas PTH(1-34) and PTH(1-84), each injected at a dose 80-fold higher than that used for LA-PTH, increased sCa and decreased sPi only modestly and transiently ( |
| Databáze: | OpenAIRE |
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