Synthesis of thieno[2,3-h]-/[3,2-h]quinolines and thieno[2,3-f] quinolines by Brønsted acid mediated cycloisomerisation

Autor:	Peter Langer, Peter Ehlers, Anika Flader, Marian Blanco Ponce, Eugenio Torres Rodríguez
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Organic Chemistry High selectivity Physical and Theoretical Chemistry 010402 general chemistry Brønsted–Lowry acid–base theory 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences
Zdroj:	Organic & Biomolecular Chemistry. 18:6531-6536
ISSN:	1477-0539 1477-0520
Popis:	Several thieno[2,3-h]-/[3,2-h]- and [2,3-f]quinolines have been synthesised from 2,3-dihalogenated pyridines or -quinolines by site-selective Pd catalysed cross-coupling reactions and Bronsted acid mediated cycloisomerisations as the final key step. This newly developed synthetic strategy is used in a modular way to synthesize diverse regioisomeric derivatives, tolerates various functional groups, and proceeds with high selectivity, and the desired final products have been isolated in high overall yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8e0421f3bcfcf641130e5d137eb9973e https://doi.org/10.1039/d0ob01194k Zobrazit plný text záznamu