The in vitro and in vivo neuroprotective activity of sodium comenate in stress
| Autor: | L. G. Khaspekov, L. V. Shurygina, A. A. Kravtsov, E. I. Zlishcheva |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant medicine.medical_treatment Sodium Glutathione reductase chemistry.chemical_element medicine.disease_cause Biochemistry Neuroprotection 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Molecular Biology chemistry.chemical_classification biology Glutathione peroxidase Glutathione 030104 developmental biology Endocrinology chemistry biology.protein 030217 neurology & neurosurgery Oxidative stress Neurotrophin |
| Zdroj: | Neurochemical Journal. 11:250-254 |
| ISSN: | 1819-7132 1819-7124 |
| DOI: | 10.1134/s1819712417020118 |
| Popis: | This paper reports an analysis of the effects of sodium comenate on neurite growth from spinal ganglia under the conditions of hydrogen peroxide-induced oxidative stress and on the glutathione antioxidant system in the brain of mice exposed to immobilization stress. It has been demonstrated that sodium comenate at the concentrations of 0.1–0.001 mM stimulates the growth of neurites from spinal ganglia exposed to oxidative stress. The most profound stimulatory effect was observed with 0.001 mM sodium comenate. The administration of sodium comenate at doses of 1, 2, and 4 mg/kg contributed to the maintenance of the GSH content and glutathione peroxidase and glutathione reductase activities at the physiologically normal state level under stress conditions. The results of the study of neurotrophic and antioxidant effects of sodium comenate in oxidative stress suggest that this compound is a highly efficient neuroprotector. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink