Pyridine Alkaloid Derivatives of Dithiophosphoric Acids and Their Antimicrobial Evaluation

Autor:	Ramazan Z. Salikhov, Elvira S. Batyeva, I. S. Nizamov, Ilnar D. Nizamov, Oscar K. Pozdeev, Marina P. Shulaeva, Ildus D. Timushev, Yevgeniy N. Nikitin, Tatyana Yu. Voznesenskaya, R. A. Cherkasov
Rok vydání:	2019
Předmět:	chemistry.chemical_compound 010405 organic chemistry Chemistry Alkaloid Pyridine Organic chemistry General Chemistry 010402 general chemistry Antimicrobial 01 natural sciences 0104 chemical sciences
Zdroj:	Asian Journal of Chemistry. 32:329-334
ISSN:	0975-427X 0970-7077
DOI:	10.14233/ajchem.2020.22381
Popis:	A new series of (S)-(–)-nicotinium salts of cyclic dithiophosphoric acids were synthesized by the reactions of 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane and 4-methyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane with (S)-(–)-nicotine. Picolinic and nicotinic acids and potassium pyridine-3-carboxylate reacted with O,O-diterpenyl dithiophosphoric acids on the basis of (1R)-endo-(+)-fenchyl alcohol and (S)-(–)-menthol to afford the corresponding 2-carboxypyridinium, 3-carboxypyridinium and potassium pyridinium-3-carboxylate dithiophosphates. The antibacterial and antifungal activity of (S)-(–)-nicotinium 4-methyl-2-mercapto-2-thiono-1,3,2- dioxaphosphorinane and salts of O,O-diterpenyl dithiophosphoric acids on the basis of nicotine and nicotinamide were evaluated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8dfb52fe38340db2ec34a3d3e07d811c https://doi.org/10.14233/ajchem.2020.22381 Zobrazit plný text záznamu