Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine
| Autor: | Wei Xue, Ming He, Jun He, Tingting Liu, Xuemei Tang, Feng Peng, Li-Wei Liu, Qing Zhou |
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| Rok vydání: | 2020 |
| Předmět: |
Ralstonia solanacearum
biology 010405 organic chemistry Chemistry General Chemical Engineering General Chemistry 010502 geochemistry & geophysics biology.organism_classification 01 natural sciences Biochemistry Industrial and Manufacturing Engineering Bismerthiazol Bacterial cell structure 0104 chemical sciences chemistry.chemical_compound Xanthomonas Materials Chemistry Myricetin Control drugs Antibacterial activity 0105 earth and related environmental sciences EC50 Nuclear chemistry |
| Zdroj: | Chemical Papers. 75:1021-1027 |
| ISSN: | 1336-9075 2585-7290 |
| Popis: | Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity against Xanthomonas oryzaepv. oryzae (Xoo), Xanthomonas axonopodispv. citri (Xac) and Ralstonia solanacearum (Rs). Among them, compounds 4m and 4p revealed excellent antibacterial activities against Rs with a concentration for 50% of maximal effect (EC50) value of 4 and 4 μg/mL, which were better than the control drugs bismerthiazol (13 μg/mL) and thiodiazole-copper (185 μg/mL). As observed using scanning electron microscope (SEM), these compounds act by causing folding and deformation of the bacterial surface, resulting in incomplete bacterial structure, so as to achieve the goal of bacteriostasis. The myricetin derivatives synthesized are expected to guide the research direction of new antibacterial agents. |
| Databáze: | OpenAIRE |
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