Prucalopride, a systemic enterokinetic, for the treatment of constipation

Autor:	Michael A. Kamm, A J Roy, Tanya Nicholls, Anton Emmanuel
Rok vydání:	2002
Předmět:	medicine.medical_specialty Prucalopride Constipation Hepatology business.industry medicine.medical_treatment digestive oral and skin physiology Gastroenterology Prokinetic agent Placebo law.invention Surgery Clinical trial Randomized controlled trial law Oral administration Internal medicine medicine Pharmacology (medical) medicine.symptom Adverse effect business medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 16:1347-1356
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2002.01272.x
Popis:	Summary Background : Laxatives are frequently ineffective in treating constipation. An alternative therapeutic approach is to target serotonin-4 receptors, which are involved in initiating peristalsis. Aim : In a double-blind, placebo-controlled trial, to assess the efficacy and safety of a systemically active serotonin-4 agonist, prucalopride. Methods : Seventy-four women with constipation were stratified into slow or normal transit groups, and each group was randomized to receive either placebo or 1 mg prucalopride daily for 4 weeks. A bowel function diary was maintained. Whole-gut and orocaecal transit, visceral sensitivity, quality of life and psychological state were assessed before and after treatment. Results : Prucalopride, not placebo, increased spontaneous stool frequency (P=0.008) and reduced time to first stool (P
Databáze:	OpenAIRE
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