| Popis: |
Optically active prostaglandin intermediates, 4( R )-(+)- and 4( S )-(−)-hydroxycyclopent-2-en-1-one derivatives, were synthesized from 3( R ),5( R )-diacetoxycyclopent-1-ene, 3( R )-acetoxy-5( R )-hydroxycyclopent-1-ene and 3( S ),5( S )-dihydroxycyclopent-1-ene obtained by microbiological hydrolysis of 3,5-diacetoxycyclopent-1-ene. The absolute configurations of all these compounds were determined by the exciton chirality method and the induced CD method. The optical purities were determined by NMR measurements of the diastereomeric esters of a versatile optically pure acid, (+)-α-methoxy-α-trifluoromethylphenylacetic acid. |
