| Autor: |
Andrew Lasslo, Kazuo K. Kimura |
| Rok vydání: |
1950 |
| Předmět: |
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| Zdroj: |
Journal of the American Pharmaceutical Association (Scientific ed.). 39:43-46 |
| ISSN: |
0095-9553 |
| DOI: |
10.1002/jps.3030390115 |
| Popis: |
Quaternary derivatives of emetine were synthesized and tested for their pharmacologic activity. These compounds showed curarelike action and marked decrease in toxicity. Structure-activity-relationships (SAR) were noted in the three quaternary derivatives. Quaternization of both nitrogens in the emetine molecule doubled the curarizing potency in comparison to the derivative in which only one of the ring nitrogens was quaternized. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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