Positive correlation between degree of parasitemia, interferon titers, and natural killer cell activity in Plasmodium falciparum-infected children

Autor:	E A Ojo-Amaize, L S Salimonu, A I Williams, O A Akinwolere, R Shabo, G V Alm, H Wigzell
Rok vydání:	1981
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 127:2296-2300
ISSN:	1550-6606 0022-1767
Popis:	Natural killer (NK) cell activity and interferon levels have been measured in the peripheral blood of children acutely ill with Plasmodium falciparum infection. The NK cell levels were found to be raised in the malaria-infected children, with a positive correlation between the degree of parasitemia and lytic activity. Comparatively high titers of antiviral activity was discovered in sera from the majority of P. falciparum-infected children, again positively correlating with the degree of parasitemia and NK levels. The characteristics of the antiviral factor indicated alpha-type interferon to be the dominating agent involved. Addition of exogenous interferon in vitro potentiated the NK levels of PBL from normal children while having no significant impact on cells from malaria-infected children.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8dbc7000acace01bc5af3ee0e9621439 https://doi.org/10.4049/jimmunol.127.6.2296 Zobrazit plný text záznamu